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Study of DSUVIA® Showing Significant Reduction in Postoperative Opioids and Better OBAS Scores Compared to Control Group to be Presented at the American Society of Regional Anesthesia (ASRA) Annual Meeting
The study was a prospective, randomized, controlled trial conducted at an ambulatory surgery center with patients aged 18-80 undergoing orthopedic surgery under general anesthesia. A total of 50 patients were included in the final analysis. There were no significant differences in baseline characteristics or duration of surgery between the two groups. The pain score on arrival to PACU was not significantly different between either group. However, patients in the SST group required 50% less opioids in the PACU (p=0.018), with significantly more of them opioid-free (36% vs 8%; p=0.037). Furthermore, SST-treated patients had improved overall benefit of analgesia scores (OBAS) compared to the control group (p=0.006). OBAS is a validated 7-item tool that assesses pain intensity, adverse effects and patients' satisfaction with analgesia.
The authors concluded that while SST 30 mcg administered intraoperatively did not affect patients' pain scores on arrival to PACU, patients that received SST did show improvement in PACU opioid requirements and OBAS scores, with more of them opioid-free in the PACU. The authors stated that the most compelling result of this study was the significant difference in OBAS and percent of opioid-free patients in the SST group, reflecting greater patient satisfaction with SST, which is more meaningful than a single pain score assessed at any given point in time. Objectively, the higher patient satisfaction was supported by the significantly lower rescue opioid requirement observed in the SST group. Limitations of the study include that the SST was not compared to an active comparator, in that it did not allow for preemptive opioid analgesia in the control group. Also, as the data collection ended at discharge, the authors were unable to assess any additional analgesic benefit of SST beyond the immediate postoperative period.
Details of the presentation and the link to the poster is as follows: https://epostersonline.com/ASRASPRING21/node/694?view=true
Title: Intraoperative sublingual sufentanil for acute pain in the ambulatory surgery center
Date & Time:
One of the investigators of the study is a paid consultant for AcelRx but was not compensated for this study.
About DSUVIA (sufentanil sublingual tablet), 30 mcg
DSUVIA®, known as DZUVEO® in
This release is intended for investors only. For more information, including important safety information and black box warning for DSUVIA, please visit www.DSUVIA.com.
For additional information about AcelRx, please visit www.acelrx.com.
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